Del Toro's performance as ex-con turned religious fanatic in despair, Jack Jordan, in Alejandro González Iñárritu's 21 Grams (2003) earned him a second Academy Award nomination for Best Supporting Actor, as well as a second Screen Actors Guild Awards nomination and a BAFTA Awards nomination for Best Actor in a Leading Role.He is also known for his scene-stealing breakout role as the eccentric, unintelligible crook Fred Fenster in The Usual Suspects (1995), which won him his first Independent Spirit Award; Benny Dalmau in Basquiat (1996), which won him a second consecutive Independent Spirit Award; Dr.and América, both which have aired in his native Brazil, the United States, Russia and in various countries in Latin America, Europe, and Asia.He has also starred in O Homem do Ano (2003) (Man of the Year).They started dating in 2002 and a few months later they were living together.
In October, 2012, Benício, during a talk show, said he was in a relationship with actress Débora Falabella.
After a long time of speculation, the two decided to take courtship.
According to the actor, the couple kept the relationship under wraps during the recording of the telenovela Avenida Brasil, who had already separated from their ex recently.
They lived together, but the relationship lasted until 2001, when Carolina broke up with him because of excessive jealousy of Murilo.
In the same year of 2001, he met Giovanna Antonelli.